Technion : la combinaison idéale, des grenades et des dattes pour prévenir les crises cardiaques et les AVC

[:fr]Un simple demi-verre de jus de grenade et une poignée de dattes, chaque jour ! C’est la combinaison gagnante contre les maladies cardiaques et les AVC, selon une équipe de chercheurs du Technion dirigée par le Professeur Michael Aviram (Faculté de médecine du Technion et Centre Rambam). Les chercheurs ont découvert que la combinaison jus de grenade et dattes, avec leurs noyaux, offre une protection maximale contre l’athérosclérose* qui peut être à l’origine de crises cardiaques ou d’AVC. Les antioxydants naturels peuvent ralentir le processus d’oxydation dans le corps et réduire le risque de crise cardiaque. Ces vingt-cinq dernières années, le Pr Aviram et son équipe ont tenté d’isoler et de rechercher ces antioxydants, afin protéger le corps humain contre l’accumulation de plaques de lipides le long de la paroi des artères.

Professor Michael Aviram of the Rappaport Faculty of Medicine (Technion) and Rambam Medical Center
Professor Michael Aviram of the Rappaport Faculty of Medicine (Technion) and Rambam Medical Center

On sait que le jus de grenade, riche en antioxydants polyphénoliques (dérivés de plantes), peut réduire significativement le stress oxydatif. Les dattes, riches en antioxydants phénoliques piégeurs de radicaux, inhibent également l’oxydation du LDL (le soi-disant «mauvais cholestérol») et stimulent l’élimination du cholestérol des cellules artérielles chargées en lipides. Le Pr Aviram pressentait que la combinaison « jus de dattes + jus de grenade » pourrait s’avérer plus bénéfique que la somme des parties. Lors d’un essai effectué sur des cellules artérielles en culture, ainsi que chez des souris atteintes d’athérosclérose, l’équipe a constaté que la triple combinaison jus de grenade + dattes + noyaux de dattes offrait une protection maximale contre le développement de l’athérosclérose, car la combinaison réduit le stress oxydatif sur la paroi artérielle de 33 % et une diminution de la teneur en cholestérol artérielle de 28 %.

Publication : Food & Function, journal of The Royal Society of Chemistry, March 26, 2015 – Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination

* L’athérosclérose se caractérise par le dépôt d’une plaque essentiellement composée de lipides (on parle d’athérome) sur la paroi des artères. A terme, ces plaques peuvent entraîner la lésion de la paroi artérielle (sclérose), conduire à l’obstruction du vaisseau, ou se rompre, avec des conséquences souvent dramatiques.

Graphical abstract: Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination

[:en]Glorious, red pomegranates and their Middle Eastern sister, luscious toffee-like dates, are delicious, increasingly trendy, and healthy to boot. As it turns out, when consumed together they are a winning combination in the war against heart disease. Just half a glass of pomegranate juice a day with a handful of dates can do the trick!

A team of researchers at the Technion-Israel Institute of Technology, led by Professor Michael Aviram of the Rappaport Faculty of Medicine and Rambam Medical Center, has discovered that the combination of pomegranate juice and dates along with their pits provide maximum protection against atherosclerosis (plaque buildup or hardening of the arteries), which can cause a heart attack or stroke.

A number of risk factors are involved in the development of atherosclerosis, including cholesterol oxidation, which leads to accumulation of lipids in the arterial wall. Natural antioxidants can slow down the oxidation process in the body, and serve to reduce the risk of heart attack. For the past 25 years, Prof. Aviram and his research team have been working on isolating and researching those antioxidants, in order to keep plaque buildup at bay.

Professor Michael Aviram of the Rappaport Faculty of Medicine (Technion) and Rambam Medical Center
Professor Michael Aviram of the Rappaport Faculty of Medicine (Technion) and Rambam Medical Center

Going into the most recent study, the team was aware of the individual benefits provided by pomegranates and dates. Pomegranate juice, rich in polyphenolic antioxidants (derived from plants), has been shown to most significantly reduce oxidative stress. Dates, which are rich sources of phenolic radical scavenger antioxidants, also inhibit the oxidation of LDL (the so-called “bad cholesterol”) and stimulate the removal of cholesterol from lipid-laden arterial cells. Prof. Aviram had a hunch that since dates and pomegranate juice are composed of different phenolic antioxidants, the combination could thus prove more beneficial than the sum of its parts.
In a trial performed on arterial cells in culture, as well as in atherosclerotic mice, the Technion team found that the triple combination of pomegranate juice, date fruits and date pits did indeed provide maximum protection against the development of atherosclerosis because the combination reduced oxidative stress in the arterial wall by 33% and decreased arterial cholesterol content by 28%.

The researchers conclude that people at high risk for cardiovascular diseases, as well as healthy individuals, could benefit from consuming the combination of half a glass of pomegranate juice (4 ounces), together with 3 dates. Ideally, the pits should be ground up into a paste and eaten as well, but even without the pits, the combination is better than either fruit alone.

Publication : Food & Function, journal of The Royal Society of Chemistry, March 26, 2015 – Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination

Graphical abstract: Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination

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